Early-Life Epilepsies and the Emerging Role of Genetic Testing.

ABSTRACT:

Importance

Early-life epilepsies are often a consequence of numerous neurodevelopmental disorders, most of which are proving to have genetic origins. The role of genetic testing in the initial evaluation of these epilepsies is not established.

Objective

To provide a contemporary account of the patterns of use and diagnostic yield of genetic testing for early-life epilepsies.

Design, setting, and participants

In this prospective cohort, children with newly diagnosed epilepsy with an onset at less than 3 years of age were recruited from March 1, 2012, to April 30, 2015, from 17 US pediatric hospitals and followed up for 1 year. Of 795 families approached, 775 agreed to participate. Clinical diagnosis of the etiology of epilepsy were characterized based on information av

SUBMITTER: Berg AT 

PROVIDER: S-EPMC5710404 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature