Perturbation of the T cell receptor repertoire occurs with increasing age in dogs.

ABSTRACT: Immunosenescence is the gradual deterioration in immune system function associated with ageing. This decline is partly due to involution of the thymus, which leads to a reduction in the output of naive T cells into the circulating lymphocyte pool. Expansion of existing naive and memory T cell populations, to compensate for the reduction in thymic output, can lead to reduced diversity in the T cell repertoire with increasing age, resulting in impairment of immune responses to novel antigenic challenges, such as during infection and vaccination. Since associations between T cell repertoire and age have only been examined in a limited number of species, to gain further insights into this relationship, we have investigated age-related changes in the canine T cell receptor (TCR) repertoire. Blo

SUBMITTER: Holder A 

PROVIDER: S-EPMC5711257 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature