Color discrimination errors associate with axial motor impairments in Parkinson's disease.

ABSTRACT:

Background

Visual function deficits are more common in imbalance-predominant compared to tremor-predominant PD suggesting a pathophysiological role of impaired visual functions in axial motor impairments.

Objective

To investigate the relationship between changes in color discrimination and motor impairments in PD while accounting for cognitive or other confounder factors.

Methods

PD subjects (n=49, age 66.7±8.3 years; Hoehn & Yahr stage 2.6±0.6) completed color discrimination assessment using the Farnsworth-Munsell 100 Hue Color Vision Test, neuropsychological, motor assessments and [¹¹C]dihydrotetrabenazine vesicular monoamine transporter type 2 PET imaging. MDS-UPDRS sub-scores for cardinal motor features were computed. Timed up and go mobility and walkin

SUBMITTER: Bohnen NI 

PROVIDER: S-EPMC5716634 | biostudies-literature | 2017 Nov-Dec

REPOSITORIES: biostudies-literature