A mass spectrometry-based proteomic analysis of Homer2-interacting proteins in the mouse brain.

ABSTRACT: In the brain, the Homer protein family modulates excitatory signal transduction and receptor plasticity through interactions with other proteins in dendritic spines. Homer proteins are implicated in a variety of psychiatric disorders such as schizophrenia and addiction. Since long Homers serve as scaffolding proteins, identifying their interacting partners is an important first step in understanding their biological function and could help to guide the design of new therapeutic strategies. The present study set out to document Homer2-interacting proteins in the mouse brain using a co-immunoprecipitation-based mass spectrometry approach where Homer2 knockout samples were used to filter out non-specific interactors. We found that in the mouse brain, Homer2 interacts with a limited subset of

SUBMITTER: Goulding SP 

PROVIDER: S-EPMC5722633 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature