Associations between adiposity and indicators of thyroid status in children and adolescents.
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ABSTRACT: Background
In adults, obesity is associated with abnormalities of thyroid function; there are fewer studies in paediatric cohorts.Objectives
To examine associations of weight and adiposity with indices of thyroid function and thyroid-related metabolic factors in children.Design/methods
A sample of 1203 children without obesity (body mass index [BMI] < 95th percentile; N = 631) and with obesity (BMI ≥ 95th percentile; N = 572), age 5-18 years, had height and weight measured (to calculate BMI-Z score for age and sex) and had blood collected in the morning for thyroid-stimulating hormone (TSH), free thyroxine (FT4) and leptin. A subset (N = 829) also underwent measurement of fat mass by dual-energy X-ray absorptiometry. Analyses examined associations of TSH and FT4 with adiposity and obesity-related conditions accounting for sociodemographic factors.Results
Thyroid-stimulating hormone was positively related to BMIz and fat mass (both p-values < 0.001). FT4 was negatively related to BMIz and fat mass (both p-values < 0.001). TSH was positively correlated to leptin (p = 0.001) even after accounting for fat mass.Conclusions
Paediatric obesity is associated with higher TSH and lower FT4 concentrations and with a greater prevalence of abnormally high TSH. Leptin concentrations may in part explain obesity's effects on thyroid status, perhaps through leptin's effects on TSH secretion.
SUBMITTER: Krause AJ
PROVIDER: S-EPMC5722653 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Publications
Associations between adiposity and indicators of thyroid status in children and adolescents.
Krause A J AJ Cines B B Pogrebniak E E Sherafat-Kazemzadeh R R Demidowich A P AP Galescu O A OA Brady S M SM Reynolds J C JC Hubbard V S VS Yanovski J A JA
Pediatric obesity 20160222 6
<h4>Background</h4>In adults, obesity is associated with abnormalities of thyroid function; there are fewer studies in paediatric cohorts.<h4>Objectives</h4>To examine associations of weight and adiposity with indices of thyroid function and thyroid-related metabolic factors in children.<h4>Design/methods</h4>A sample of 1203 children without obesity (body mass index [BMI] < 95th percentile; N = 631) and with obesity (BMI ≥ 95th percentile; N = 572), age 5-18 years, had height and weight measure ...[more]
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