Associations between adiposity and indicators of thyroid status in children and adolescents.

ABSTRACT:

Background

In adults, obesity is associated with abnormalities of thyroid function; there are fewer studies in paediatric cohorts.

Objectives

To examine associations of weight and adiposity with indices of thyroid function and thyroid-related metabolic factors in children.

Design/methods

A sample of 1203 children without obesity (body mass index [BMI] < 95th percentile; N = 631) and with obesity (BMI ≥ 95th percentile; N = 572), age 5-18 years, had height and weight measured (to calculate BMI-Z score for age and sex) and had blood collected in the morning for thyroid-stimulating hormone (TSH), free thyroxine (FT4) and leptin. A subset (N = 829) also underwent measurement of fat mass by dual-energy X-ray absorptiometry. Analyses examined associations of TSH and FT4 wit

SUBMITTER: Krause AJ 

PROVIDER: S-EPMC5722653 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature