Ontology highlight
ABSTRACT:
SUBMITTER: Yamazaki S
PROVIDER: S-EPMC5727176 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Scientific reports 20171212 1
Interleukin (IL)-17-producing T helper (Th17) cells are crucial for host defense against extracellular microbes and pathogenesis of autoimmune diseases. Here we show that the AP-1 transcription factor JunB is required for Th17 cell development. Junb-deficient CD4<sup>+</sup> T cells are able to develop in vitro into various helper T subsets except Th17. The RNA-seq transcriptome analysis reveals that JunB is crucial for the Th17-specific gene expression program. Junb-deficient mice are completel ...[more]