Pronounced strain-specific chemosensory receptor gene expression in the mouse vomeronasal organ.

ABSTRACT:

Background

The chemosensory system plays an important role in orchestrating sexual behaviors in mammals. Pheromones trigger sexually dimorphic behaviors and different mouse strains exhibit differential responses to pheromone stimuli. It has been speculated that differential gene expression in the sensory organs that detect pheromones may underlie sexually-dimorphic and strain-specific responses to pheromone cues.

Results

We have performed transcriptome analyses of the mouse vomeronasal organ, a sensory organ recognizing pheromones and interspecies cues. We find little evidence of sexual dimorphism in gene expression except for Xist, an essential gene for X-linked gene inactivation. Variations in gene expression are found mainly among strains, with genes from immune response

SUBMITTER: Duyck K 

PROVIDER: S-EPMC5727874 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature