HLA Association with Drug-Induced Adverse Reactions.

ABSTRACT: Adverse drug reactions (ADRs) remain a common and major problem in healthcare. Severe cutaneous adverse drug reactions (SCARs), such as Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) with mortality rate ranges from 10% to more than 30%, can be life threatening. A number of recent studies demonstrated that ADRs possess strong genetic predisposition. ADRs induced by several drugs have been shown to have significant associations with specific alleles of human leukocyte antigen (HLA) genes. For example, hypersensitivity to abacavir, a drug used for treating of human immunodeficiency virus (HIV) infection, has been proposed to be associated with allele 57:01 of HLA-B gene (terms HLA-B^∗57:01). The incidences of abacavir hypersensitivity are much h

SUBMITTER: Fan WL 

PROVIDER: S-EPMC5733150 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature