Ontology highlight
ABSTRACT:
SUBMITTER: Tamura M
PROVIDER: S-EPMC5736608 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Tamura Makoto M Spellman Timothy J TJ Rosen Andrew M AM Gogos Joseph A JA Gordon Joshua A JA
Nature communications 20171219 1
Cross-frequency coupling supports the organization of brain rhythms and is present during a range of cognitive functions. However, little is known about whether and how long-range cross-frequency coupling across distant brain regions subserves working memory. Here we report that theta-slow gamma coupling between the hippocampus and medial prefrontal cortex (mPFC) is augmented in a genetic mouse model of cognitive dysfunction. This increased cross-frequency coupling is observed specifically when ...[more]