Runx3 programs CD8⁺ T cell residency in non-lymphoid tissues and tumours.

ABSTRACT: Tissue-resident memory CD8⁺ T (T_RM) cells are found at common sites of pathogen exposure, where they elicit rapid and robust protective immune responses. However, the molecular signals that control T_RM cell differentiation and homeostasis are not fully understood. Here we show that mouse T_RM precursor cells represent a unique CD8⁺ T cell subset that is distinct from the precursors of circulating memory cell populations at the levels of gene expression and chromatin accessibility. Using computational and pooled in vivo RNA interference screens, we identify the transcription factor Runx3 as a key regulator of T_RM cell differentiation and homeostasis. Runx3 was required to establish T_RM cell populations in diverse ti

SUBMITTER: Milner JJ 

PROVIDER: S-EPMC5747964 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature