Augmentative therapies do not potentiate the antidepressant-like effects of deep brain stimulation in rats.

ABSTRACT:

Background

Clinical trials have shown promising results with the use of subcallosal cingulate gyrus deep brain stimulation (DBS) for treatment-resistant depression. However, strategies to manage patients who do not respond to this therapy have not been explored in detail. In rats, DBS in the ventromedial prefrontal cortex (vmPFC) induces a significant antidepressant-like response in the forced swim test (FST). We have used this test to investigate potential interactions between DBS and clinically used augmentative regimens.

Methods

Rats undergoing the FST were treated with vmPFC DBS along with different augmentative drugs, namely buspirone, risperidone and pindolol. Locomotor activity was tested in an open field.

Results

DBS induced a significant reduction in immobili

SUBMITTER: Laver B 

PROVIDER: S-EPMC5756073 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature