In vitro-in vivo studies of the quantitative effect of calcium, multivitamins and milk on single dose ciprofloxacin bioavailability.
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ABSTRACT:
SUBMITTER: Dey B
PROVIDER: S-EPMC5762247 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
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<i>In vitro-in vivo</i> studies of the quantitative effect of calcium, multivitamins and milk on single dose ciprofloxacin bioavailability.
Dey Baishakhi B Katakam Prakash P Assaleh Fathi H FH Chandu Babu Rao BR Adiki Shanta Kumari SK Mitra Analava A
Journal of pharmaceutical analysis 20150310 6
Ciprofloxacin, commonly used in India as an anti-microbial for prolonged use in chronic and non-specific indications, may affect the bioavailability of the drug. The drug prescribed is commonly taken with multivitamins, calcium and milk. A simple and reliable analytical methodology obtaining a correlation with <i>in vivo</i> urinary excretion studies using UV and HPLC and <i>in vitro</i> dissolution studies (IVIVC) has shown a significant increase in elimination rate of ciprofloxacin co-administ ...[more]
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