Dataset Information

Improved cognitive performance and event-related potential changes following working memory training in patients with multiple sclerosis.

ABSTRACT:

Background

Few studies of cognitive rehabilitation in multiple sclerosis (MS) have targeted working memory specifically.

Objective

We examined the effects of n-back working memory training on cognitive performance and brain function in patients with MS.

Methods

Patients with MS (n = 12) and healthy controls (HC; n = 12) underwent 20 sessions of n-back working memory training. Before and after training (pre- and posttest) cognitive event-related potential (ERP) measures were obtained during a 3-back task. In addition, a battery of cognitive tests was administered.

Results

Following n-back training, both MS patients and HCs showed significant improvement on tests of working memory, processing speed, complex attention, and reasoning ability. MS and HCs also exhibited an enhancement of N2 ERP component amplitude, and earlier N2 and P3 latencies, following n-back training.

Conclusions

Targeted training of working memory with the n-back task may improve cognitive function in MS. Enhancement of N2 ERP component amplitude and shorter N2 and P3 latency following training in patients with MS is consistent with plasticity of neural processes that are involved in working memory.

SUBMITTER: Covey TJ

PROVIDER: S-EPMC5768274 | biostudies-literature | 2018 Jan-Mar

REPOSITORIES: biostudies-literature

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Publications

Improved cognitive performance and event-related potential changes following working memory training in patients with multiple sclerosis.

Covey Thomas J TJ Shucard Janet L JL Benedict Ralph Hb RH Weinstock-Guttman Bianca B Shucard David W DW

Multiple sclerosis journal - experimental, translational and clinical 20180111 1

<h4>Background</h4>Few studies of cognitive rehabilitation in multiple sclerosis (MS) have targeted working memory specifically.<h4>Objective</h4>We examined the effects of <i>n</i>-back working memory training on cognitive performance and brain function in patients with MS.<h4>Methods</h4>Patients with MS (<i>n</i> = 12) and healthy controls (HC; <i>n</i> = 12) underwent 20 sessions of <i>n</i>-back working memory training. Before and after training (pre- and posttest) cognitive event-related p ...[more]

PMID: 29348927

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Project description:BackgroundAdaptive computerized working memory (WM) training has shown favorable effects on cerebral cortical thickness as compared to non-adaptive training in healthy individuals. However, knowledge of WM training-related morphological changes in mild cognitive impairment (MCI) is limited.ObjectiveThe primary objective of this double-blind randomized study was to investigate differences in longitudinal cortical thickness trajectories after adaptive and non-adaptive WM training in patients with MCI. We also investigated the genotype effects on cortical thickness trajectories after WM training combining these two training groups using longitudinal structural magnetic resonance imaging (MRI) analysis in Freesurfer.MethodMagnetic resonance imaging acquisition at 1.5 T were performed at baseline, and after four- and 16-weeks post training. A total of 81 individuals with MCI accepted invitations to undergo 25 training sessions over 5 weeks. Longitudinal Linear Mixed effect models investigated the effect of adaptive vs. non-adaptive WM training. The LME model was fitted for each location (vertex). On all statistical analyzes, a threshold was applied to yield an expected false discovery rate (FDR) of 5%. A secondary LME model investigated the effects of LMX1A and APOE-ε4 on cortical thickness trajectories after WM training.ResultsA total of 62 participants/patients completed the 25 training sessions. Structural MRI showed no group difference between the two training regimes in our MCI patients, contrary to previous reports in cognitively healthy adults. No significant structural cortical changes were found after training, regardless of training type, across all participants. However, LMX1A-AA carriers displayed increased cortical thickness trajectories or lack of decrease in two regions post-training compared to those with LMX1A-GG/GA. No training or training type effects were found in relation to the APOE-ε4 gene variants.ConclusionThe MCI patients in our study, did not have improved cortical thickness after WM training with either adaptive or non-adaptive training. These results were derived from a heterogeneous population of MCI participants. The lack of changes in the cortical thickness trajectory after WM training may also suggest the lack of atrophy during this follow-up period. Our promising results of increased cortical thickness trajectory, suggesting greater neuroplasticity, in those with LMX1A-AA genotype need to be validated in future trials.

Dataset Information

Improved cognitive performance and event-related potential changes following working memory training in patients with multiple sclerosis.

Background

Objective

Methods

Results

Conclusions

Publications

Improved cognitive performance and event-related potential changes following working memory training in patients with multiple sclerosis.

Similar Datasets

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