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The addition of a developmental factor, unc-62, to already long-lived worms increases lifespan and healthspan.

ABSTRACT: Aging is a complex trait that is affected by multiple genetic pathways. A relatively unexplored approach is to manipulate multiple independent aging pathways simultaneously in order to observe their cumulative effect on lifespan. Here, we report the phenotypic characterization of a strain with changes in five aging pathways: (1) mitochondrial reactive oxygen species (ROS) production, (2) innate immunity, (3) stress response, (4) metabolic control and (5) developmental regulation in old age. The quintuply modified strain has a lifespan that is 160% longer than the transgenic control strain. Additionally, the quintuply modified strain maintains several physiological markers of aging for a longer time than the transgenic control. Our results support a modular approach as a general scheme to study how multiple pathways interact to achieve extreme longevity.

SUBMITTER: Sagi D

PROVIDER: S-EPMC5769649 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature

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The addition of a developmental factor, <i>unc-62</i>, to already long-lived worms increases lifespan and healthspan.

Sagi Dror D

Biology open 20171215 12

Aging is a complex trait that is affected by multiple genetic pathways. A relatively unexplored approach is to manipulate multiple independent aging pathways simultaneously in order to observe their cumulative effect on lifespan. Here, we report the phenotypic characterization of a strain with changes in five aging pathways: (1) mitochondrial reactive oxygen species (ROS) production, (2) innate immunity, (3) stress response, (4) metabolic control and (5) developmental regulation in old age. The ...[more]

PMID: 29055022

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