Molecular and functional signatures in a novel Alzheimer's disease mouse model assessed by quantitative proteomics.

ABSTRACT:

Background

Alzheimer's disease (AD), the most common neurodegenerative disorder, is characterized by the deposition of extracellular amyloid plaques and intracellular neurofibrillary tangles. To understand the pathological mechanisms underlying AD, developing animal models that completely encompass the main features of AD pathologies is indispensable. Although mouse models that display pathological hallmarks of AD (amyloid plaques, neurofibrillary tangles, or both) have been developed and investigated, a systematic approach for understanding the molecular characteristics of AD mouse models is lacking.

Methods

To elucidate the mechanisms underlying the contribution of amyloid beta (Aβ) and tau in AD pathogenesis, we herein generated a novel animal model of AD, namely the AD-l

SUBMITTER: Kim DK 

PROVIDER: S-EPMC5771139 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature