Altered pattern of monocyte differentiation and monocyte-derived TGF-?1 in severe asthma.

ABSTRACT: CD14+ monocytes contain precursors for macrophages and fibrocytes, known to be involved in regulating airway remodeling in human asthma and distinguishable by the PM-2K marker. We sought to identify circulating subsets of PM-2K+ macrophage-like cells and evaluate their relationships to lung function, severity and control status. Circulating PM-2K+ macrophage-like cells and fibrocytes could be identified and distinguished between normal individuals (N?=?152) and asthmatic subjects (N?=?133) using multi-parametric flow cytometry. PM-2K+ macrophage-like cells were found to be significantly lower in asthmatic subjects, particularly noted for the CD14-PM-2K+ subset and PM-2K+CCR7-CD86+ cells in subjects with poor lung function (FEV%/FVC%?

SUBMITTER: Hung CH 

PROVIDER: S-EPMC5772494 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature