An obesity-associated gut microbiome reprograms the intestinal epigenome and leads to altered colonic gene expression.

ABSTRACT:

Background

The gut microbiome, a key constituent of the colonic environment, has been implicated as an important modulator of human health. The eukaryotic epigenome is postulated to respond to environmental stimuli through alterations in chromatin features and, ultimately, gene expression. How the host mediates epigenomic responses to gut microbiota is an emerging area of interest. Here, we profile the gut microbiome and chromatin characteristics in colon epithelium from mice fed either an obesogenic or control diet, followed by an analysis of the resultant changes in gene expression.

Results

The obesogenic diet shapes the microbiome prior to the development of obesity, leading to altered bacterial metabolite production which predisposes the host to obesity. This microbiota-

SUBMITTER: Qin Y 

PROVIDER: S-EPMC5782396 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature