Morphine treatment leads to temporal modulation of the gut microbiome

ABSTRACT: Opioid analgesics are frequently prescribed in the United States and worldwide. However, serious side effects such as addiction, immunosuppression and gastrointestinal symptoms limit long term use. In the current study using a chronic morphine-murine model a longitudinal approach was undertaken to investigate the role of morphine modulation of gut microbiome as a mechanism contributing to the negative consequences associated with opioids use. The results revealed a significant shift in the gut microbiome and metabolome within 24 hours following morphine treatment when compared to placebo. Morphine induced gut microbial dysbiosis exhibited distinct characteristic signatures profiles including significant increase in communities associated with pathogenic function, decrease in communities as

INSTRUMENT(S): Illumina MiSeq

ORGANISM(S): mouse gut metagenome

SUBMITTER: Fuyuan Wang 

PROVIDER: E-MTAB-5550 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress