Opioid-induced gut microbial disruption leads to gut barrier compromise and sustained systemic inflammation.

ABSTRACT: Morphine and its pharmacological derivatives are the most prescribed analgesics for moderate to severe pain management. However, chronic use of morphine reduces pathogen clearance and induces bacterial translocation across the gut barrier. The enteric microbiome has been shown to play a critical role in the preservation of the mucosal barrier function and metabolic homeostasis. Here, we show for the first time, using bacterial 16s rDNA sequencing, that chronic morphine treatment significantly alters the gut microbial composition and induces preferential expansion of the gram-positive pathogenic and reduction of bile-deconjugating bacterial strains. A significant reduction in both primary and secondary bile acid levels was seen in the gut, but not in the liver with morphine treatment. Morph

INSTRUMENT(S): Applied Biosciences, Illumina MiSeq, none, None

ORGANISM(S): Mus musculus domesticus

SUBMITTER: Santanu Banerjee 

PROVIDER: E-MTAB-3722 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress