Association of Cerebral Amyloid-β Aggregation With Cognitive Functioning in Persons Without Dementia.

ABSTRACT:

Importance

Cerebral amyloid-β aggregation is an early event in Alzheimer disease (AD). Understanding the association between amyloid aggregation and cognitive manifestation in persons without dementia is important for a better understanding of the course of AD and for the design of prevention trials.

Objective

To investigate whether amyloid-β aggregation is associated with cognitive functioning in persons without dementia.

Design, setting, and participants

This cross-sectional study included 2908 participants with normal cognition and 4133 with mild cognitive impairment (MCI) from 53 studies in the multicenter Amyloid Biomarker Study. Normal cognition was defined as having no cognitive concerns for which medical help was sought and scores within the normal range on co

SUBMITTER: Jansen WJ 

PROVIDER: S-EPMC5786156 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature