Dataset Information

Coffee Drinking and Mortality in 10 European Countries: A Multinational Cohort Study.

ABSTRACT:

Background

The relationship between coffee consumption and mortality in diverse European populations with variable coffee preparation methods is unclear.

Objective

To examine whether coffee consumption is associated with all-cause and cause-specific mortality.

Design

Prospective cohort study.

Setting

10 European countries.

Participants

521 330 persons enrolled in EPIC (European Prospective Investigation into Cancer and Nutrition).

Measurements

Hazard ratios (HRs) and 95% CIs estimated using multivariable Cox proportional hazards models. The association of coffee consumption with serum biomarkers of liver function, inflammation, and metabolic health was evaluated in the EPIC Biomarkers subcohort (n = 14 800).

Results

During a mean follow-up of 16.4 years, 41 693 deaths occurred. Compared with nonconsumers, participants in the highest quartile of coffee consumption had statistically significantly lower all-cause mortality (men: HR, 0.88 [95% CI, 0.82 to 0.95]; P for trend < 0.001; women: HR, 0.93 [CI, 0.87 to 0.98]; P for trend = 0.009). Inverse associations were also observed for digestive disease mortality for men (HR, 0.41 [CI, 0.32 to 0.54]; P for trend < 0.001) and women (HR, 0.60 [CI, 0.46 to 0.78]; P for trend < 0.001). Among women, there was a statistically significant inverse association of coffee drinking with circulatory disease mortality (HR, 0.78 [CI, 0.68 to 0.90]; P for trend < 0.001) and cerebrovascular disease mortality (HR, 0.70 [CI, 0.55 to 0.90]; P for trend = 0.002) and a positive association with ovarian cancer mortality (HR, 1.31 [CI, 1.07 to 1.61]; P for trend = 0.015). In the EPIC Biomarkers subcohort, higher coffee consumption was associated with lower serum alkaline phosphatase; alanine aminotransferase; aspartate aminotransferase; γ-glutamyltransferase; and, in women, C-reactive protein, lipoprotein(a), and glycated hemoglobin levels.

Limitations

Reverse causality may have biased the findings; however, results did not differ after exclusion of participants who died within 8 years of baseline. Coffee-drinking habits were assessed only once.

Conclusion

Coffee drinking was associated with reduced risk for death from various causes. This relationship did not vary by country.

Primary funding source

European Commission Directorate-General for Health and Consumers and International Agency for Research on Cancer.

SUBMITTER: Gunter MJ

PROVIDER: S-EPMC5788283 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Coffee Drinking and Mortality in 10 European Countries: A Multinational Cohort Study.

Gunter Marc J MJ Murphy Neil N Cross Amanda J AJ Dossus Laure L Dartois Laureen L Fagherazzi Guy G Kaaks Rudolf R Kühn Tilman T Boeing Heiner H Aleksandrova Krasimira K Tjønneland Anne A Olsen Anja A Overvad Kim K Larsen Sofus Christian SC Redondo Cornejo Maria Luisa ML Agudo Antonio A Sánchez Pérez María José MJ Altzibar Jone M JM Navarro Carmen C Ardanaz Eva E Khaw Kay-Tee KT Butterworth Adam A Bradbury Kathryn E KE Trichopoulou Antonia A Lagiou Pagona P Trichopoulos Dimitrios D Palli Domenico D Grioni Sara S Vineis Paolo P Panico Salvatore S Tumino Rosario R Bueno-de-Mesquita Bas B Siersema Peter P Leenders Max M Beulens Joline W J JWJ Uiterwaal Cuno U CU Wallström Peter P Nilsson Lena Maria LM Landberg Rikard R Weiderpass Elisabete E Skeie Guri G Braaten Tonje T Brennan Paul P Licaj Idlir I Muller David C DC Sinha Rashmi R Wareham Nick N Riboli Elio E

Annals of internal medicine 20170711 4

<h4>Background</h4>The relationship between coffee consumption and mortality in diverse European populations with variable coffee preparation methods is unclear.<h4>Objective</h4>To examine whether coffee consumption is associated with all-cause and cause-specific mortality.<h4>Design</h4>Prospective cohort study.<h4>Setting</h4>10 European countries.<h4>Participants</h4>521 330 persons enrolled in EPIC (European Prospective Investigation into Cancer and Nutrition).<h4>Measurements</h4>Hazard ra ...[more]

PMID: 28693038

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Project description:ImportanceSoft drinks are frequently consumed, but whether this consumption is associated with mortality risk is unknown and has been understudied in European populations to date.ObjectiveTo examine the association between total, sugar-sweetened, and artificially sweetened soft drink consumption and subsequent total and cause-specific mortality.Design, setting, and participantsThis population-based cohort study involved participants (n = 451 743 of the full cohort) in the European Prospective Investigation into Cancer and Nutrition (EPIC), an ongoing, large multinational cohort of people from 10 European countries (Denmark, France, Germany, Greece, Italy, the Netherlands, Norway, Spain, Sweden, and the United Kingdom), with participants recruited between January 1, 1992, and December 31, 2000. Excluded participants were those who reported cancer, heart disease, stroke, or diabetes at baseline; those with implausible dietary intake data; and those with missing soft drink consumption or follow-up information. Data analyses were performed from February 1, 2018, to October 1, 2018.ExposureConsumption of total, sugar-sweetened, and artificially sweetened soft drinks.Main outcomes and measuresTotal mortality and cause-specific mortality. Hazard ratios (HRs) and 95% CIs were estimated using multivariable Cox proportional hazards regression models adjusted for other mortality risk factors.ResultsIn total, 521 330 individuals were enrolled. Of this total, 451 743 (86.7%) were included in the study, with a mean (SD) age of 50.8 (9.8) years and with 321 081 women (71.1%). During a mean (range) follow-up of 16.4 (11.1 in Greece to 19.2 in France) years, 41 693 deaths occurred. Higher all-cause mortality was found among participants who consumed 2 or more glasses per day (vs consumers of <1 glass per month) of total soft drinks (hazard ratio [HR], 1.17; 95% CI, 1.11-1.22; P < .001), sugar-sweetened soft drinks (HR, 1.08; 95% CI, 1.01-1.16; P = .004), and artificially sweetened soft drinks (HR, 1.26; 95% CI, 1.16-1.35; P < .001). Positive associations were also observed between artificially sweetened soft drinks and deaths from circulatory diseases (≥2 glasses per day vs <1 glass per month; HR, 1.52; 95% CI, 1.30-1.78; P < .001) and between sugar-sweetened soft drinks and deaths from digestive diseases (≥1 glass per day vs <1 glass per month; HR, 1.59; 95% CI, 1.24-2.05; P < .001).Conclusions and relevanceThis study found that consumption of total, sugar-sweetened, and artificially sweetened soft drinks was positively associated with all-cause deaths in this large European cohort; the results are supportive of public health campaigns aimed at limiting the consumption of soft drinks.

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Dataset Information

Coffee Drinking and Mortality in 10 European Countries: A Multinational Cohort Study.

Background

Objective

Design

Setting

Participants

Measurements

Results

Limitations

Conclusion

Primary funding source

Publications

Coffee Drinking and Mortality in 10 European Countries: A Multinational Cohort Study.

Similar Datasets

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