Early development in Rett syndrome - the benefits and difficulties of a birth cohort approach.

ABSTRACT:

Purposes

Typically, early (pre-diagnostic) development in individuals later diagnosed with Rett syndrome (RTT) has been investigated retrospectively using parent reports, medical records and analysis of home videos. In recent years, prospective research designs have been increasingly applied to the investigation of early development in individuals with late phenotypical onset disorders, for example, autism spectrum disorder.

Methods

In this study, data collected by the Danish National Birth Cohort lent itself to prospective exploration of the early development of RTT, in particular early motor-, speech-language, and socio-communicative behaviors, mood, and sleep.

Results and conclusions

Despite limitations, this quasi prospective methodology proved promising. In order

SUBMITTER: Marschik PB 

PROVIDER: S-EPMC5796587 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature