Cellular basis of angiotensin-(1-7)-induced augmentation of left ventricular functional performance in heart failure.

ABSTRACT:

Background

Angiotensin-(1-7) [Ang-(1-7)] exhibits cardiovascular effects opposite those of angiotensin II (Ang II), thus providing protection against heart disease. However, how Ang-(1-7) imparts cardioprotection is unclear, and its direct cardiac effects are controversial. Whether heart failure (HF) alters cardiac contractile responses to Ang-(1-7) remains undetermined. We tested the hypothesis that in HF, Ang-(1-7) may produce positive modulation on [Ca²⁺]_i regulation, enhancing left ventricular (LV) and myocyte contraction and relaxation via Ang-(1-7) Mas receptor coupled with nitric oxide (NO)/bradykinin (BK)-mediated mechanism.

Methods and results

We measured LV contractility changes after Ang-(1-7) (650ng/kg, iv) and compared myocyte functional an

SUBMITTER: Zhang X 

PROVIDER: S-EPMC5798248 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature