Sphingosine kinase 2 supports the development of BCR/ABL-independent acute lymphoblastic leukemia in mice.

ABSTRACT:

Background

Sphingosine kinase (SphK) 2 has been implicated in the development of a range of cancers and inhibitors of this enzyme are currently in clinical trial. We have previously demonstrated a role for SphK2 in the development of acute lymphoblastic leukemia (ALL).

Methods

In this and our previous study we use mouse models: in the previous study the disease was driven by the proto-oncogene BCR/ABL1, while in this study cancer risk was elevated by deletion of the tumor suppressor ARF.

Results

Mice lacking ARF and SphK2 had a significantly reduced incidence of ALL compared mice with wild type SphK2.

Conclusions

These results show that the role of SphK2 in ALL development is not limited to BCR/ABL1 driven disease extending the potential use of inhibitors of th

SUBMITTER: Xie V 

PROVIDER: S-EPMC5800079 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature