S100A9⁺ MDSC and TAM-mediated EGFR-TKI resistance in lung adenocarcinoma: the role of RELB.

ABSTRACT:

Background

Monocytic myeloid-derived suppressor cells (MDSCs), particularly the S100A9+ subset, has been shown initial clinical relevance. However, its role in EGFR-mutated lung adenocarcinoma, especially to EGFR-tyrosine kinase inhibitor (EGFR-TKI) is not clear. In a clinical setting of EGFR mutated lung adenocarcinoma, a role of the MDSC apart from T cell suppression was also investigated.

Results

Blood monocytic S100A9⁺ MDSC counts were higher in lung cancer patients than healthy donors, and were associated with poor treatment response and shorter progression-free survival (PFS). S100A9⁺ MDSCs in PBMC were well correlated to tumor infiltrating CD68⁺ and S100A9⁺ cells, suggesting an origin of TAMs. Patient's MDMs, mostly from S10

SUBMITTER: Feng PH 

PROVIDER: S-EPMC5800931 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature