Gender-related differences in clinicopathological characteristics and renal outcomes of Chinese patients with IgA nephropathy.

ABSTRACT:

Background

The prognostic effect of gender on immunoglobulin A nephropathy (IgAN) is not clear. We explored gender-related differences in clinicopathological features and renal outcomes in IgAN.

Methods

This was a single-centre retrospective study. Patients were divided into two groups according to gender. The clinicopathological features at biopsy and renal outcomes during the follow-up were collected and analysed. Renal outcomes were defined as the doubling of baseline serum creatinine and end-stage renal disease (ESRD) (estimated glomerular filtration rate < 15 mL/min/1.73 m², dialysis, or renal transplantation). The prognostic effects of gender were evaluated by Cox regression models.

Results

A total of 988 eligible IgAN patients were enrolled, and the

SUBMITTER: Deng W 

PROVIDER: S-EPMC5804055 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature