Ontology highlight
ABSTRACT:
SUBMITTER: Leonardi I
PROVIDER: S-EPMC5805464 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20180101 6372
Intestinal fungi are an important component of the microbiota, and recent studies have unveiled their potential in modulating host immune homeostasis and inflammatory disease. Nonetheless, the mechanisms governing immunity to gut fungal communities (mycobiota) remain unknown. We identified CX3CR1<sup>+</sup> mononuclear phagocytes (MNPs) as being essential for the initiation of innate and adaptive immune responses to intestinal fungi. CX3CR1<sup>+</sup> MNPs express antifungal receptors and acti ...[more]