Considerations and guidelines for mouse metabolic phenotyping in diabetes research.
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ABSTRACT:
SUBMITTER: Alquier T
PROVIDER: S-EPMC5805661 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Publications
Considerations and guidelines for mouse metabolic phenotyping in diabetes research.
Alquier Thierry T Poitout Vincent V
Diabetologia 20171116 3
Mice are the most commonly used species in preclinical research on the pathophysiology of metabolic diseases. Although they are extremely useful for identifying pathways, mechanisms and genes regulating glucose and energy homeostasis, the specificities of the various mouse models and methodologies used to investigate a metabolic phenotype can have a profound impact on experimental results and their interpretation. This review aims to: (1) describe the most commonly used experimental tests to ass ...[more]
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