Delta Vs Gamma Auditory Steady State Synchrony in Schizophrenia.

ABSTRACT:

Background

Delta band (1-4 Hz) neuronal responses support the precision and stability of auditory processing, and a deficit in delta band synchrony may be relevant to auditory domain symptoms in schizophrenia patients.

Methods

Delta band synchronization elicited by a 2.5 Hz auditory steady state response (ASSR) paradigm, along with those from theta (5 Hz), alpha (10 Hz), beta (20 Hz), gamma (40 Hz), and high gamma (80 Hz) frequency ASSR, were compared in 128 patients with schizophrenia, 108 healthy controls, and 55 first-degree relatives (FDR) of patients.

Results

Delta band synchronization was significantly impaired in patients compared with controls (F = 18.3, P < .001). There was a significant 2.5 Hz by 40 Hz ASSR interaction (P = .023), arising from a greater redu

SUBMITTER: Puvvada KC 

PROVIDER: S-EPMC5814801 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature