Varenicline for tobacco-dependence treatment in alcohol-dependent smokers: A randomized controlled trial.

ABSTRACT: BACKGROUND:Tobacco use is prevalent among persons with alcohol abuse and dependence. Varenicline has been shown to be the most effective pharmacotherapy for smoking cessation and may decrease alcohol consumption. The purpose of this study was to evaluate the efficacy of 12 weeks of varenicline for increasing smoking abstinence rates in smokers with alcohol abuse or dependence. METHODS:Participants were eligible for enrollment if they were 18 years or older, smoked 10 or more cigarettes per day for at least 6 months, had current alcohol abuse or dependence, and were interested in quitting smoking. Participants were randomly assigned to receive 12 weeks of varenicline 1 mg twice daily or matching placebo. The primary end point was 7-day point prevalence smoking abstinence at week 12. RESULTS

SUBMITTER: Hurt RT 

PROVIDER: S-EPMC5818285 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature