Association of Systemic Inflammation and Sarcopenia With Survival in Nonmetastatic Colorectal Cancer: Results From the C SCANS Study.

ABSTRACT:

Importance

Systemic inflammation and sarcopenia are easily evaluated, predict mortality in many cancers, and are potentially modifiable. The combination of inflammation and sarcopenia may be able to identify patients with early-stage colorectal cancer (CRC) with poor prognosis.

Objective

To examine associations of prediagnostic systemic inflammation with at-diagnosis sarcopenia, and determine whether these factors interact to predict CRC survival, adjusting for age, ethnicity, sex, body mass index, stage, and cancer site.

Design, setting, and participants

A prospective cohort of 2470 Kaiser Permanente patients with stage I to III CRC diagnosed from 2006 through 2011.

Exposures

Our primary measure of inflammation was the neutrophil to lymphocyte ratio (NLR). We

SUBMITTER: Feliciano EMC 

PROVIDER: S-EPMC5824285 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature