Potential Diagnostic Power of Blood Circular RNA Expression in Active Pulmonary Tuberculosis.

ABSTRACT:

Background

Circular RNAs (circRNAs) are a class of novel RNAs with important biological functions, and aberrant expression of circRNAs has been implicated in human diseases. However, the feasibility of using blood circRNAs as disease biomarkers is largely unknown.

Methods

We explored the potential of using human peripheral blood mononuclear cell (PBMC) circRNAs as marker molecules to diagnose active pulmonary tuberculosis (TB).

Findings

First, we demonstrated that circRNAs are widely expressed in human PBMCs and that many are abundant enough to be detected. Second, we found that the magnitude of PBMC circRNAs in TB patients was higher than that in the paired healthy controls. Compared with host linear transcripts, the circRNAs within several pathways are disproportion

SUBMITTER: Qian Z 

PROVIDER: S-EPMC5828303 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature