Synergistic interplay between the two major bone minerals, hydroxyapatite and whitlockite nanoparticles, for osteogenic differentiation of mesenchymal stem cells.

ABSTRACT: The inorganic part of human bone is mainly composed of hydroxyapatite (HAP: Ca₁₀(PO₄)₆(OH)₂) and whitlockite (WH: Ca₁₈Mg₂(HPO₄)₂(PO₄)₁₂) minerals, where the WH phase occupies up to 20-35% of total weight. These two bone minerals have different crystal structures and physicochemical properties, implying their distinguished role in bone physiology. However, until now, the biological significance of the presence of a certain ratio between HAP and WH in bone is unclear. To address this fundamental question, bone mimetic scaffolds are designed to encapsulate human mesenchymal stem cells (MSCs) for assessing their osteogenic activity depending on different ratios of HAP and WH. Interesti

SUBMITTER: Cheng H 

PROVIDER: S-EPMC5839653 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature