Using an engineered glutamate-gated chloride channel to silence sensory neurons and treat neuropathic pain at the source.
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ABSTRACT:
SUBMITTER: Weir GA
PROVIDER: S-EPMC5841150 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
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Using an engineered glutamate-gated chloride channel to silence sensory neurons and treat neuropathic pain at the source.
Weir Greg A GA Middleton Steven J SJ Clark Alex J AJ Daniel Tarun T Khovanov Nikita N McMahon Stephen B SB Bennett David L DL
Brain : a journal of neurology 20171001 10
See Basbaum (doi:10.1093/brain/awx227) for a scientific commentary on this article. Peripheral neuropathic pain arises as a consequence of injury to sensory neurons; the development of ectopic activity in these neurons is thought to be critical for the induction and maintenance of such pain. Local anaesthetics and anti-epileptic drugs can suppress hyperexcitability; however, these drugs are complicated by unwanted effects on motor, central nervous system and cardiac function, and alternative mo ...[more]
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