Kinetics of Double-Stranded DNA Viremia After Allogeneic Hematopoietic Cell Transplantation.

ABSTRACT:

Background

Improved understanding of double-stranded DNA (dsDNA) virus kinetics after hematopoietic cell transplantation (HCT) would facilitate development of therapeutic strategies.

Methods

We tested weekly plasma samples from 404 patients through day 100 after allogeneic HCT for cytomegalovirus (CMV), human herpesvirus (HHV) 6A and 6B, BK polyomavirus (BKV), adenovirus (AdV), and Epstein-Barr virus (EBV) using quantitative polymerase chain reaction. Episodes lasting ≤1 week were defined as blips and >1 week as persistent. We described virus-specific kinetics, analyzed the association of virus area under the curve (AUC) with overall mortality, and identified risk factors for persistent episodes.

Results

We identified 428 episodes of CMV, 292 of BKV, 224 of HHV-6B, 46

SUBMITTER: Hill JA 

PROVIDER: S-EPMC5850428 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature