Graft-infiltrating PD-L1^hi cross-dressed dendritic cells regulate antidonor T cell responses in mouse liver transplant tolerance.

ABSTRACT: Although a key role of cross-dressing has been established in immunity to viral infection and more recently in the instigation of transplant rejection, its role in tolerance is unclear. We investigated the role of intragraft dendritic cells (DCs) and cross-dressing in mouse major histocompatibility complex (MHC)-mismatched liver transplant tolerance that occurs without therapeutic immunosuppression. Although donor interstitial DCs diminished rapidly after transplantation, they were replaced in the liver by host DCs that peaked on postoperative day (POD) 7 and persisted indefinitely. Approximately 60% of these recipient DCs displayed donor MHC class I, indicating cross-dressing. By contrast, only a very minor fraction (0%-2%) of cross-dressed DCs (CD-DCs) was evident in the spleen. CD-DCs s

SUBMITTER: Ono Y 

PROVIDER: S-EPMC5856603 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature