Ontology highlight
ABSTRACT:
SUBMITTER: Lorsch ZS
PROVIDER: S-EPMC5856766 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Nature communications 20180316 1
Most people exposed to stress do not develop depression. Animal models have shown that stress resilience is an active state that requires broad transcriptional adaptations, but how this homeostatic process is regulated remains poorly understood. In this study, we analyze upstream regulators of genes differentially expressed after chronic social defeat stress. We identify estrogen receptor α (ERα) as the top regulator of pro-resilient transcriptional changes in the nucleus accumbens (NAc), a key ...[more]