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Copper-catalyzed aminoalkynylation of alkenes with hypervalent iodine reagents.

ABSTRACT: A copper-catalyzed aminoalkynylation of alkenes is achieved with ethynylbenziodoxolone (EBX) reagents under mild conditions with only 1 mol% copper catalyst. This transformation allows for rapid construction of diverse important azahetereocycles and installation of valuable alkyne groups in one step. The developed method features remarkable substrate scope for both terminal and internal alkenes as well as different alkynyl groups, presenting great potential for broad applications in synthesis, bioconjugation, and molecular imaging.

SUBMITTER: Shen K

PROVIDER: S-EPMC5857935 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature

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Copper-catalyzed aminoalkynylation of alkenes with hypervalent iodine reagents.

Shen Kun K Wang Qiu Q

Chemical science 20171016 12

A copper-catalyzed aminoalkynylation of alkenes is achieved with ethynylbenziodoxolone (EBX) reagents under mild conditions with only 1 mol% copper catalyst. This transformation allows for rapid construction of diverse important azahetereocycles and installation of valuable alkyne groups in one step. The developed method features remarkable substrate scope for both terminal and internal alkenes as well as different alkynyl groups, presenting great potential for broad applications in synthesis, b ...[more]

PMID: 29568474

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