Key genes and regulatory networks involved in the initiation, progression and invasion of colorectal cancer.
Ontology highlight
ABSTRACT: Aim
Until now, identification of drug targets for treatment of patients with specific stages of colorectal cancer (CRC) has remained a challenging field of research. Herein, we aimed to identify the key genes and regulatory networks involved in each stage of CRC.Results
The results of gene expression profiles were integrated with protein-protein interaction networks, and topologically analyzed. The most important regulatory genes (e.g., CDK1, UBC, ESR1 and ATXN1) and signaling pathways (e.g., Wnt, MAPK and JAK-STAT) in CRC initiation, progression and metastasis were identified. In vitro analysis confirmed some in silico findings.Conclusion
Our study introduces functional hub genes, subnetworks, prioritizes signaling pathways and novel biomarkers in CRC that may guide further development of targeted therapy programs.
SUBMITTER: Asghari M
PROVIDER: S-EPMC5859335 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Publications
Key genes and regulatory networks involved in the initiation, progression and invasion of colorectal cancer.
Asghari Matin M Abazari Mohammad Foad MF Bokharaei Hanieh H Aleagha Maryam Nouri MN Poortahmasebi Vahdat V Askari Hassan H Torabinejad Sepehr S Ardalan Abbas A Negaresh Navid N Ataei Atousa A Pazooki Parisa P Poorebrahim Mansour M
Future science OA 20180124 3
<h4>Aim</h4>Until now, identification of drug targets for treatment of patients with specific stages of colorectal cancer (CRC) has remained a challenging field of research. Herein, we aimed to identify the key genes and regulatory networks involved in each stage of CRC.<h4>Results</h4>The results of gene expression profiles were integrated with protein-protein interaction networks, and topologically analyzed. The most important regulatory genes (e.g., <i>CDK1</i>, <i>UBC</i>, <i>ESR1</i> and <i ...[more]
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