Identification of Key Genes and Pathways Involved in Circulating Tumor Cells in Colorectal Cancer.

ABSTRACT:

Background

Characterization of the features associated with circulating tumor cells (CTCs) is one of major interests for predicting clinical outcome of colorectal cancer (CRC) patients. However, the molecular features of CTCs remain largely unclear.

Methods

For identification of key genes and pathways, GSE31023, contained CTCs from six metastatic CRC patients and three controls, was retrieved for differentially expressed gene (DEG) analysis. Protein-protein interaction networks of DEGs were constructed. Hub genes from the network were prognostic analyzed, as well as the association with tumor-infiltrating immune cells.

Results

1353 DEGs were identified between the CTC and control groups, with 403 genes upregulated and 950 downregulated. 32 pathways were significantly

SUBMITTER: Pan R 

PROVIDER: S-EPMC8813301 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature