A functional SNP upstream of the ADRB2 gene is associated with COPD.

ABSTRACT:

Background

Previous studies have suggested that β₂-adrenergic receptor (ADRB2) is associated with COPD. However, the role of genetic polymorphisms in ADRB2 on COPD has not been evaluated yet.

Methods

In this study, SNaPshot genotyping, luciferase assay, chromatin immunoprecipitation and real-time polymerase chain reaction were adopted to investigate the association between ADRB2 genetic polymorphisms and COPD, comprehensively.

Results

One single nucleotide polymorphism (rs12654778), located upstream of ADRB2, showed a significant association with COPD by the logistic regression analysis after adjusting for age, sex and smoking history (p=0.04) in 200 COPD patients and 222 controls from southwest Chinese population. Further

SUBMITTER: Li JX 

PROVIDER: S-EPMC5859892 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature