Annotating function to differentially expressed LincRNAs in myelodysplastic syndrome using a network-based method.

ABSTRACT:

Motivation

Long non-coding RNAs (lncRNAs) have been implicated in the regulation of diverse biological functions. The number of newly identified lncRNAs has increased dramatically in recent years but their expression and function have not yet been described from most diseases. To elucidate lncRNA function in human disease, we have developed a novel network based method (NLCFA) integrating correlations between lncRNA, protein coding genes and noncoding miRNAs. We have also integrated target gene associations and protein-protein interactions and designed our model to provide information on the combined influence of mRNAs, lncRNAs and miRNAs on cellular signal transduction networks.

Results

We have generated lncRNA expression profiles from the CD34+ haematopoietic stem and prog

SUBMITTER: Liu K 

PROVIDER: S-EPMC5860060 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature