Concomitant suppression of T_H2 and T_H17 cell responses in allergic asthma by targeting retinoic acid receptor-related orphan receptor γt.

ABSTRACT:

Background

Allergic asthma is a heterogeneous chronic inflammatory disease of the airways with a massive infiltration of eosinophils or neutrophils mediated by allergen-specific T_H2 and T_H17 cells, respectively. Therefore successful treatment of allergic asthma will require suppression of both T_H2 and T_H17 cells.

Objective

We sought to investigate the role of the T_H17 cell pathway in regulating T_H2 cell responses in allergic asthma.

Methods

Allergic asthma was induced by intranasal challenge with proteinase allergens in C57BL/6, Il17a^-/-Il17f^-/-, and retinoic acid receptor-related orphan receptor γt (RORγt)^gfp/gfp mice. A pharmacologic RORγt inhibitor was used to evaluat

SUBMITTER: Na H 

PROVIDER: S-EPMC5862762 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature