Patterns of shared signatures of recent positive selection across human populations.

ABSTRACT: Signatures of recent positive selection often overlap across human populations, but the question of how often these overlaps represent a single ancestral event remains unresolved. If a single selective event spread across many populations, the same sweeping haplotype should appear in each population and the selective pressure could be common across populations and environments. Identifying such shared selective events could identify genomic loci and human traits important in recent history across the globe. In addition, genomic annotations that recently became available could help attach these signatures to a potential gene and molecular phenotype selected across populations. Here, we present a catalogue of selective sweeps in humans, and identify those that overlap and share a sweeping ha

SUBMITTER: Johnson KE 

PROVIDER: S-EPMC5866773 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature