EFF-1 fusogen promotes phagosome sealing during cell process clearance in Caenorhabditis elegans.

ABSTRACT: Phagocytosis of dying cells is critical in development and immunity^1-3. Although proteins for recognition and engulfment of cellular debris following cell death are known^4,5, proteins that directly mediate phagosome sealing are uncharacterized. Furthermore, whether all phagocytic targets are cleared using the same machinery is unclear. Degeneration of morphologically complex cells, such as neurons, glia and melanocytes, produces phagocytic targets of various shapes and sizes located in different microenvironments^6,7. Thus, such cells offer unique settings to explore engulfment programme mechanisms and specificity. Here, we report that dismantling and clearance of a morphologically complex Caenorhabditis elegans epithelial cell requires separate cell soma, p

SUBMITTER: Ghose P 

PROVIDER: S-EPMC5876135 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature