MicroRNA profiling during directed differentiation of cortical interneurons from human-induced pluripotent stem cells.

ABSTRACT: Induced pluripotent stem cells (iPSCs) are useful for modeling neuron development and related diseases. Cortical interneurons are essential players in neuropsychiatric diseases such as autism. miRNAs are a class of pivotal regulators in neural differentiation. Using a previously established model of cortical interneuron differentiation from human embryonic stem cells, we profiled miRNAs involved in differentiation from human iPSCs. A number of miRNAs were modulated in the differentiation process. This study captured the temporal in vitro neurogenesis from iPSCs to mature cortical interneurons. The specific miRNAs identified at each stage of differentiation are of potential use for drug discovery and prospective clinical applications.

SUBMITTER: Tu J 

PROVIDER: S-EPMC5881541 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature