24 vs. 72 hours of hypothermia for pediatric cardiac arrest: A pilot, randomized controlled trial.

ABSTRACT: AIM:Children surviving cardiac arrest (CA) lack proven neuroprotective therapies. The role of biomarkers in assessing response to interventions is unknown. We hypothesized that 72 versus 24?h of hypothermia (HT) would produce more favorable biomarker profiles after pediatric CA. METHODS:This single center pilot randomized trial tested HT (33?±?1?°C) for 24 vs. 72?h in 34 children with CA. Children comatose after return of circulation aged 1 week to 17 years and treated with HT by their physician were eligible. Serum was collected twice daily on days 1-4 and once on day 7. Mortality was assessed at 6 months. RESULTS:Patient characteristics, baseline biomarker concentrations, and adverse events were similar between groups. Eight (47%) and 4 (24%) children died in the 24?h and 72?h groups, p?=?.3. Serum neuron specific enolase (NSE) concentration was increased in the 24 vs. 72?h group at 84?h-96?h (median [interquartile range] 47.7 [3.9, 79.9] vs. 1.4 [0.0, 11.1] ng/ml, p?=?.02) and on day 7 (18.2 [3.2, 74.0] vs. 2.6 [0.0, 12.8] ng/ml, p?=?.047). Serum S100b was increased in the 24?h vs. 72?h group at 12?h-24?h, 36?h-84?h, and on day 7, all p?

SUBMITTER: Fink EL 

PROVIDER: S-EPMC5899619 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature