MicroRNA meta-signature of oral cancer: evidence from a meta-analysis.

ABSTRACT:

Aim

It was the aim of the study to identify commonly deregulated miRNAs in oral cancer patients by performing a meta-analysis of previously published miRNA expression profiles in cancer and matched normal non-cancerous tissue in such patients.

Material and methods

Meta-analysis included seven independent studies analyzed by a vote-counting method followed by bioinformatic enrichment analysis.

Results

Amongst seven independent studies included in the meta-analysis, 20 miRNAs were found to be deregulated in oral cancer when compared with non-cancerous tissue. Eleven miRNAs were consistently up-regulated in three or more studies (miR-21-5p, miR-31-5p, miR-135b-5p, miR-31-3p, miR-93-5p, miR-34b-5p, miR-424-5p, miR-18a-5p, miR-455-3p, miR-450a-5p, miR-21-3p), and nine were

SUBMITTER: Zeljic K 

PROVIDER: S-EPMC5901467 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature