Parenting stress and DNA methylation among African Americans in the InterGEN Study.

ABSTRACT:

Introduction

General life stress has been associated with altered DNA methylation in individuals of African Ancestry, although the relationship between parenting stress and DNA methylation has not been described. The purpose of this study was to examine the relationship between maternal parenting stress and DNA methylation among African Ancestry mother-child dyads.

Methods

We evaluated epigenome-wide DNA methylation relative to parenting stress in 74 mother-child dyads using linear mixed models.

Results

Significant variation in maternal DNA methylation at 95 CpG sites was associated with level of parenting stress. Notably, we identified a change in DNA methylation associated with poly (ADP-ribose) polymerase-1, which plays a key role in stress signaling. We did not id

SUBMITTER: Wright ML 

PROVIDER: S-EPMC5915805 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature