Association between polymorphism of tumor necrosis factor alpha (tnfα) in the region -308 g/a with tinnitus in the elderly with a history of occupational noise exposure.

ABSTRACT:

Context

Tinnitus is a common disorder that occurs frequently across all strata of population and has an important health concern and is often associated with different forms of the hearing loss of varying severity.

Aims

To investigate the association between the polymorphism of tumor necrosis factor alpha (TNFα) in the region -308 G/A with the susceptibility to tinnitus in individuals with the history of exposure to occupational noise.

Settings and design

This was a cross-sectional study with a sample of 179 independent elderly people above 60 years of age.

Materials and methods

Information on exposure to occupational noise was obtained by interviews. Audiological evaluation was performed using pure tone audiometry and genotyped through polymerase chain reactio

SUBMITTER: Marchiori LLM 

PROVIDER: S-EPMC5926314 | biostudies-literature | 2018 Mar-Apr

REPOSITORIES: biostudies-literature